Institute of Physiology, Academy of Sciences of the Czech Republic
A loss of cognitive functions accompanying natural aging and various pathological processes of central nervous system is connected with weakening of cholinergic transmission and disappearance of cholinergic neurons in basal forebrain.
The Dolezal group is concerned with the field of cholinergic physiology, biochemistry and pharmacology and neurotransmission. They will study the effect the diet has on synaptic function. This is a very direct basic science read-out for effectiveness an plays an important role for our in-vitro as much as our in vivo studies to select the right diets before they enter a clinical trial as much as to define the MOA. Dolezal has previously discovered that DHA alters synaptic transmission in the cholinergic pathway.