A specific multi-nutrient diet reduces Alzheimer-like pathology in young adult AβPPswe/PS1dE9 mice.
Nutrients are known to influence neuronal membrane synthesis, composition, and function. There is cumulating evidence showing that the effects of nutrient supplementation may be much stronger when all necessary nutrients for such processes are given together. We now tested whether a dietary intervention (called ‘Fortasyn Connect‘, FC), with specific nutrients that are involved in membrane synthesis, would affect the early development of Alzheimer-like changes in the brains of model mice. We compared the effects of FC with a Control diet and with a diet that provided only a few nutrients from FC. It is shown that especially the combined administration of the nutrients in FC reduced plaque formation and neurodegeneration.