Improved spatial learning strategy and memory in aged Alzheimer AβPPswe/PS1dE9 mice on a multi-nutrient diet.

Lifestyle factors like diet may influence the onset and progression of Alzheimer's disease (AD). Amulti-nutrient diet, Fortasyn, containing nutritional precursors and cofactors for membrane synthesis, viz. docosahexaenoic acid, eicosapentaenoic acid, uridine-mono-phosphate, choline, phospholipids, folic acid, vitamins B6, B12, C, E, and selenium, has an ameliorating effect on cognitive deficits in an AD mouse model. In the present study we analyzed learning strategies of 11-month-old AD mice. Both transgenic and nontransgenic mice on the multinutrient diet, This specific nutrient combination showed a tendency to improve searching behavior in the AD mice by increasing the use of a more efficient search strategy and improving their swim efficiency by decreasing the latency to reach the former

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